Streptozotocin is equally diabetogenic whether administered to fed or fasted mice
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چکیده
منابع مشابه
Tumor Growth in Fed and Fasted Mice
(7) involved the determination of total radioac tivity in tumor, as compared with liver, kidney, and spleen over a 6-day time period following the injection of glycine-f2-C'4. The experiment was carried out with the rapidly growing Flexner Jobling rat carcinoma. To determine the effect of limiting the nitrogen turnover to a host-tumor re lationship, half the animals were fasted after the inject...
متن کاملGlucose metabolism in jejunal mucosa of fed, fasted, and streptozotocin-diabetic rats.
ANDERSON, JAMES Mr. Glucose metabolism in jejunal mucosa of fed, fasted, and streptototocin-diabetic rats. Am. J. Physiol. 226(l) : 226229. 1974.2Glycolytic and gluconeogenic enzyme activities and glycolytic rates were measured in the jejunal mucosa of rats. Tissue homogenates have high rates of glycolysis, which may make a significant contribution to the energy requirements of jejunal mucosa. ...
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The relationship between the dose of intravenously administered streptozotocin (a N-nitroso derivative of glucosamine) and the diabetogenic response has been explored by use of the following indices of diabetogenic action: serum glucose, urine volume, and glycosuria, ketonuria, serum immunoreactive insulin (IRI), and pancreatic IRI content. Diabetogenic activity could be demonstrated between th...
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Diabetes mellitus (DM), a chronic metabolic disorder, is increasing tremendously around the world. Assessment of interventions designed to prevent disease progression in humans takes years. On the other hand, the use of plants as diabetic agent needs preclinical test to obtain scientific evidence. Therefore, appropriate experimental animal model of diabetes mellitus is essential tools for under...
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ژورنال
عنوان ژورنال: Laboratory Animals
سال: 2013
ISSN: 0023-6772,1758-1117
DOI: 10.1177/0023677213489548